A metabolic crosstalk between liposarcoma and muscle sustains tumor growth. - Metabohub : Infrastructure nationale en métabolomique et fluxomique
Article Dans Une Revue Nature Communications Année : 2024

A metabolic crosstalk between liposarcoma and muscle sustains tumor growth.

Résumé

Dedifferentiated and Well-differentiated liposarcoma are characterized by a systematic amplification of the Murine Double Minute 2 (MDM2) oncogene. We demonstrate that p53-independent metabolic functions of chromatin-bound MDM2 are exacerbated in liposarcoma and mediate an addiction to serine metabolism to sustain tumor growth. However, the origin of exogenous serine remains unclear. Here, we show that elevated serine levels in mice harboring liposarcoma-patient derived xenograft, released by distant muscle is essential for liposarcoma cell survival. Repressing interleukine-6 expression, or treating liposarcoma cells with Food and Drugs Administration (FDA) approved anti-interleukine-6 monoclonal antibody, decreases de novo serine synthesis in muscle, impairs proliferation, and increases cell death in vitro and in vivo. This work reveals a metabolic crosstalk between muscle and liposarcoma tumor and identifies anti-interleukine-6 as a plausible treatment for liposarcoma patients.
Fichier principal
Vignette du fichier
2024 Manteaux et al., A metabolic crosstalk.pdf (1023.21 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04696400 , version 1 (13-09-2024)

Identifiants

Citer

Gabrielle Manteaux, Alix Amsel, Blanche Riquier-Morcant, Jaime Prieto Romero, Laurie Gayte, et al.. A metabolic crosstalk between liposarcoma and muscle sustains tumor growth.. Nature Communications, 2024, 15 (1), pp.7940. ⟨10.1038/s41467-024-51827-3⟩. ⟨hal-04696400⟩
0 Consultations
0 Téléchargements

Altmetric

Partager

More