Dopamine builds and reveals reward-associated latent behavioral attractors - Fondation pour la Recherche Médicale
Article Dans Une Revue Nature Communications Année : 2024

Dopamine builds and reveals reward-associated latent behavioral attractors

Résumé

Phasic variations in dopamine levels are interpreted as a teaching signal reinforcing rewarded behaviors. However, behavior also depends on the motivational, neuromodulatory effect of phasic dopamine. In this study, we reveal a neurodynamical principle that unifies these roles in a recurrent network-based decision architecture embodied through an action-perception loop with the task space, the MAGNet model. Dopamine optogenetic conditioning in mice was accounted for by an embodied network model in which attractors encode internal goals. Dopamine-dependent synaptic plasticity created "latent" attractors, to which dynamics converged, but only locally. Attractor basins were widened by dopamine-modulated synaptic excitability, rendering goals accessible globally, i.e. from distal positions. We validated these predictions optogenetically in mice: dopamine neuromodulation suddenly and specifically attracted animals toward rewarded locations, without off-target motor effects. We thus propose that motivational dopamine reveals dopamine-built attractors representing potential goals in a behavioral landscape.
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Dates et versions

hal-04795017 , version 1 (01-09-2022)
hal-04795017 , version 2 (21-11-2024)

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Jérémie Naudé, Matthieu X B Sarazin, Sarah Mondoloni, Bernadette Hannesse, Eléonore Vicq, et al.. Dopamine builds and reveals reward-associated latent behavioral attractors. Nature Communications, 2024, 15 (1), pp.9825. ⟨10.1038/s41467-024-53976-x⟩. ⟨hal-04795017v2⟩
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