Galleria mellonella as a screening tool to study virulence factors of Aspergillus fumigatus - Epidémiologie des Maladies Chroniques en zone tropicale
Article Dans Une Revue (Article De Synthèse) Virulence Année : 2021

Galleria mellonella as a screening tool to study virulence factors of Aspergillus fumigatus

Résumé

The invertebrate Galleria mellonella has increasingly and widely been used in the last few years to study complex host-microbe interactions. Aspergillus fumigatus is one of the most pathogenic fungi causing life-threatening diseases in humans and animals. Galleria mellonella larvae has been proven as a reliable model for the analysis of pathogenesis and virulence factors, enable to screen a large number of A. fumigatus strains. This review describes the different uses of G. mellonella to study A. fumigatus and provides a comparison of the different protocols to trace fungal pathogenicity. The review also includes a summary of the diverse mutants tested in G. mellonella, and their respective contribution to A. fumigatus virulence. Previous investigations indicated that G. mellonella should be considered as an interesting tool even though a mammalian model may be required to complete and verify initial data.
Fichier principal
Vignette du fichier
Galleria mellonella as a screening tool to study virulence factors of Aspergillus fumigatus.pdf (2.34 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03687390 , version 1 (04-09-2024)

Identifiants

Citer

Marie-Fleur Durieux, Élise Melloul, Sana Jemel, Lolita Roisin, Marie-Laure Dardé, et al.. Galleria mellonella as a screening tool to study virulence factors of Aspergillus fumigatus. Virulence, 2021, 12 (1), p. 818-834. ⟨10.1080/21505594.2021.1893945⟩. ⟨hal-03687390⟩
23 Consultations
0 Téléchargements

Altmetric

Partager

More